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How long does it take for enteric-coated capsules to dissolve in the digestive system?

The time it takes for enteric-coated capsules to dissolve in the digestive system can vary depending on several factors, including the specific formulation of the enteric coating and individual physiological differences. Generally, enteric-coated capsules are designed to resist dissolution in the acidic environment of the stomach and instead dissolve in the alkaline conditions of the small intestine.

The enteric coating is typically designed to withstand the acidic pH of the stomach, which has a pH range of approximately 1.5 to 3.5. It provides a protective barrier that prevents the contents of the capsule from being released too early and potentially causing stomach irritation or degradation of the medication.

Once the enteric-coated capsule reaches the small intestine, which has a higher pH ranging from 6 to 7.4, the enteric coating dissolves, allowing the contents of the capsule to be released and absorbed. The dissolution time can vary, but it is generally within the range of 30 minutes to 2 hours in the small intestine.

It's important to note that the specific dissolution time can be influenced by factors such as the composition of the enteric coating, the individual's gastrointestinal transit time, and any underlying gastrointestinal conditions that may affect the rate of capsule dissolution.

If you have concerns about the dissolution time of a specific enteric-coated capsule, it is advisable to consult with a healthcare professional or refer to the product's prescribing information for more accurate and specific information.

Enteric-coated Hollow Capsules

Product introduction: Enteric gelatin hollow capsules are made of gelatin and enteric coating materials.
Product Category: Pharmaceutical Excipients
Product application: It is often used in special packaging for drugs or health care products that are irritating to the stomach or are unstable in the presence of acid, and that need to be dissolved in the intestine and exert their curative effect.
Product function: Intestinal positioning administration, reducing adverse reactions. Targeted fixed-point release: no disintegration and no cracks in gastric juice for two hours, and drug release in intestinal juice within 30 minutes, providing a perfect solution for protein polypeptide drugs and live bacteria preparations.
Product advantages: Intestinal-targeted drug delivery can improve drug efficacy and reduce dosage, and at the same time, it can reduce adverse reactions and facilitate the use of patients; it can also avoid the degradation of oral protein polypeptide drugs or health care products, providing the best absorption site for drugs.