News Details

Home / News / Industry News / How refillable are empty gelatin capsules?

How refillable are empty gelatin capsules?

When evaluating the refillability of empty gelatin capsules, the first things to consider are their particle size and shape. These two factors directly affect the uniformity of drug filling and the filling rate of the capsule. The particle size of the capsule must match the filled drug particles or powder to ensure that the drug can enter the capsule smoothly. In addition, the shape of the capsule should also be designed reasonably so that the drug particles or powder can be evenly distributed during the filling process to avoid being too dense or sparse locally.

Liquidity is another key factor. Good fluidity ensures that the drug is evenly distributed during the filling process and can flow freely inside the capsule without clogging or accumulation. The fluidity inside a capsule is affected by many factors, including the particle size and shape of the drug, the surface properties of the capsule material, and the filling speed. Therefore, flowability needs to be closely monitored during the filling process to ensure uniform filling of the drug.

The sealing performance of the capsule is also one of the important indicators for evaluating its fillability. Once filled, the capsule must be able to seal effectively to prevent leakage or oxidation of the drug. Good sealing performance can ensure that the medicine inside the capsule is not contaminated or affected by the external environment during storage and transportation, thereby maintaining the stability and effectiveness of the medicine.

Additionally, capsule tolerability also needs to be considered. During the filling process, the capsule may be subject to a certain degree of pressure and therefore requires a certain degree of tolerance to prevent the capsule from rupture or deformation during the filling process. Insufficient tolerance may lead to disruption of the capsule structure, affecting its fillability and the quality of the final product.

The chemical stability of capsule materials is also one of the important considerations in evaluating fillability. The capsule material must be compatible with the drug being filled and must not react chemically during filling and storage, thereby affecting the stability and effectiveness of the drug. Therefore, when selecting capsule materials, attention must be paid to their compatibility with drugs, and capsule preparation conditions must be strictly controlled during the production process to ensure the chemical stability of the capsule materials and the safety of the filled drugs.

Empty Gelatin Capsules
Product introduction: Gelatin hollow capsules are capsule shells with specific color and shape made of gelatin as the main raw material.
Product Category: Pharmaceutical Excipients
Product application: It is often used for special packaging of drugs or health care products with bad odor, light sensitivity and instability in case of humidity and heat.
Product function: Capsules made of hollow capsules do not need binders and many auxiliary materials in the production process, and are easy to disintegrate and release in gastric juice, which can improve bioavailability compared with tablets and pills.
Product advantages: It has the advantages of accurate dosage, easy to carry and use, and safe sealing.